2,3-MDPV

2 3-MDPV is a potential psychoactive designer drug. It is a structural isomer of 2 3-MDPV, a designer drug that has been detected in products marketed as bath salts, plant food, and tablets.1,2,3 This product is intended for forensic purposes. 2 3-MDPV For Sale online.

The abuse of ‘bath salts’ has raised concerns because of their adverse effects, which include delirium, violent behavior, and suicide ideation in severe cases. The bath salt constituent 3,4-methylenedioxypyrovalerone (MDPV) has been closely linked to these and other adverse effects. The abnormal behavioral pattern produced by acute high-dose MDPV intake suggests possible disruptions of neural communication between brain regions. Therefore, we determined if MDPV exerts disruptive effects on brain functional connectivity, particularly in areas of the prefrontal cortex. Male rats were imaged following administration of a single dose of MDPV (0.3, 1.0, or 3.0 mg/kg) or saline. Resting state brain blood oxygenation level-dependent (BOLD) images were acquired at 4.7 T. To determine the role of dopamine transmission in MDPV-induced changes in functional connectivity, a group of rats received the dopamine D₁/D₂ receptor antagonist cis-flupenthixol (0.5 mg/kg) 30 min before MDPV. MDPV dose-dependently reduced functional connectivity. Detailed analysis of its effects revealed that connectivity between frontal cortical and striatal areas was reduced. This included connectivity

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2,3-Methylenedioxy Pyrovalerone (2,3-MDPV) is a potential psychoactive designer drug. It is a structural isomer of 3,4-MDPV, a designer drug that has been detected in products marketed as bath salts, plant food, and tablets.^1,2,3 This product is intended for forensic purposes.